Including players from Ampthill, Bedford, Luton, Dunstablians, Stockwood Park, Leighton Buzzard and Biggleswade, Beds soon had the lead when Jake Hodges fed the backs and Harry Sawford Smith was swiftly under the posts.
Jacob Ives, playing 15, converted and went on to kick six in total on the night.
East Northants battled hard and had Beds camped in their 22 for a prolonged period, but crash ball after crash ball was defended with great discipline.
Adam Jones went over twice, while Sawford-Smith added another to complete his hat-trick to bring the half to an end.
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Beds switched off at the restart as East Northants scored twice and kicked a conversion to bring them right back into the game.
However, a rallying call from coaches and captain on the night Mike Batty had the side refocused.
Tries from Archie Dandy and Batty followed while, with the last play, the final score arrived.
Forward Renier DeBeer caught well from the kick, attacked and took the pack with him.
Dontae Brown cleared out two men from the ruck allowing Ben Slawinski to make a sweet flat pass out to Harry Smith.
Jake Roberts followed and took a lovely pass and crashed through to end a great move as Beds enjoyed their biggest win in two years.
The team now go into a three-week training camp ahead of the quadrangular tournament where they hope to become regional champions for the third time.