The scheduled opening day clash between the two teams was postponed due to the riots that swept the country back in August, meaning that Luton have been playing catch-up again this season.
Opponents Telford were only formed back in May 2004 by supporters of Telford United after it became clear that the previous club would cease to exist.
They have swiftly moved through the leagues though winning the Northern Premier League to reach the Conference North, before securing promotion last season after a 3-2 victory over Guiseley in the play-off final.
Telford have strengthened their squad in recent weeks, with striker Chris Sharp, son of ex-Everton and Scotland player Graeme brought in to bolster the frontline.
Clubs all set for big kick-off as Bedford Town, Ampthill Town and Real Bedford begin campaigns
Setchell feels Bedford Town deserved their opening point at Stratford
Bedford's women cricketers make it three wins in a row
Ampthill hit six to get the season off and running in style
George Bernard Shaw treated in Luton after tree fall
Former Bath and Forest Green goalkeeper Ryan Robinson has joined on non-contract terms too, while the Bucks have also brought in another striker, with former Boston forward Spencer Weir-Daley now on board.
The club have enjoyed a promising start to the campaign too with a 1-0 win at York City the highlight, while they also defeated Newport County 2-1, although they are currently without a win in three matches.
Team news: Hatters are hopeful that Curtis Osano will recover from his toe injury, but new signing Jamie Hand misses out with suspension after picking up his fifth booking of the season on Saturday.
Quartet Shane Blackett, Dan Gleeson, Freddie Murray and George Pilkington are stepping up their training, but Charlie Henry remains on the sidelines.
In charge: Andy Sinton – skilful winger who started his career at Camridge United, before a spell at Brentford, but it was at QPR where he really made his name, with over 150 appearances.
England caps followed, as Sinton represented his country 12 times, before moving to Spurs, Wolves, Burton Albion and Bromsgrove Roveres until winding his career down at Fleet Town with over 600 professional games to his name.
It was at Fleet that he wet his feet managerially too, spending five years with the club, before joining Telford in May 2010.
One to watch: Chris Sharp – striker signed recently from the New Saints, who scored twice against Hatters in the Welsh side’s 3-0 victory during pre-season.
During his career he has played against Belgium champions Anderlecht in the Champions League and has also featured in the Europa League.
Made his Bucks debut in the 3-2 defeat at Southport, but has proved a prolific goalscorer wherever he has played, netting 34 goals in 41 appearances for Bangor City
Top scorers: Amari Morgan-Smith (4) – Greg Mills/Sean Newton (2)
Odds: Telford win 3/1 - Luton win 4/5 - Draw 5/2.