More than 22 coaches from around the country will descend on the controversial Thurleigh detention centre on Saturday (March 12).
The protest is being organised by Movement for Justice (MFJ) and will be led by ex-detainees and asylum seekers.
MFJ’s Antonia Bright said: “The time for talk is done; we are fighting for action. We will not stop until the travesty of justice and human rights that is immigration detention is ended once and for all.
“We promise there will be more demonstrations, more disruption of business-as-usual in detention and more action by detainees demanding their freedom.”
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Saturday’s march will be the seventh demonstration at Yarl’s Wood led by Movement for Justice with other organisations.
Previous demonstrations have seen women join in from inside, waving handmade signs from their windows.